Recent blog posts
Chugai collaborates with Helsinn to promote the antiemetic drug AKYNZEO
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Chugai collaborates with Helsinn to promote the antiemetic drug AKYNZEO
25 June 2024
On June 12, Helsinn Healthcare announced the renewal of its distribution and licensing agreement with Chugai Pharma Europe to promote AKYNZEO® (a combination drug containing netupitant and palonosetron) in the UK and Ireland.
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Reflections on the FDA Hold of Medilink Therapeutics' HER3 ADC YL202/BNT326
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Reflections on the FDA Hold of Medilink Therapeutics' HER3 ADC YL202/BNT326
21 June 2024
What is the structure of YL202/BNT326, and why is it exhibiting such high toxicity?
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Eli Lilly: GLP-1R/GCGR/GIPR Triagonist Reduces Liver Fat Content by 86%
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5 min read
Eli Lilly: GLP-1R/GCGR/GIPR Triagonist Reduces Liver Fat Content by 86%
20 June 2024
The study indicated that Retatrutide (LY3437943), a GLP-1R-related triple receptor agonist currently under clinical development, demonstrated significant efficacy and favorable safety in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD).
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Research Progress on GPCR Antibody Drugs
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18 min read
Research Progress on GPCR Antibody Drugs
18 June 2024
Aimovig™ (erenumab) is an injectable human monoclonal antibody (mAb) co-developed and co-marketed by Novartis and Amgen, indicated for the preventive treatment of migraines in adults.
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Science: AlphaFold2 Structural Models Guide Drug Discovery
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Science: AlphaFold2 Structural Models Guide Drug Discovery
18 June 2024
The researchers conducted a prospective docking of extensive compound libraries against the unoptimized AlphaFold2 (AF2) models of the σ2 receptor and the 5-HT2A receptor.
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Structure Therapeutics GLP-1R Small Molecule Agonist GSBR-1290 Preclinical and Clinical Data
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6 min read
Structure Therapeutics GLP-1R Small Molecule Agonist GSBR-1290 Preclinical and Clinical Data
5 June 2024
On June 3, the official website of Structure Therapeutics announced top-line data from its 12-week clinical Phase 2a study of the investigational drug GSBR-1290 in obesity.
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Biogen Acquires HI-Bio for $1.8 Billion to Expand Immunology Portfolio
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8 min read
Biogen Acquires HI-Bio for $1.8 Billion to Expand Immunology Portfolio
5 June 2024
On May 22, Biogen Inc. and Human Immunology Biosciences (HI-Bio) announced an acquisition agreement. Biogen will acquire HI-Bio for $1.15 billion upfront and up to $650 million in potential milestone payments.
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Nature: Dual-active molecules targeting GLP-1R and NMDA receptors exhibit superior anti-obesity effects
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5 min read
Nature: Dual-active molecules targeting GLP-1R and NMDA receptors exhibit superior anti-obesity effects
21 May 2024
On May 15th, the journal Nature published a research paper titled "GLP-1-directed NMDA receptor antagonism for obesity treatment" by the Novo Nordisk team.
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The Dramatic 24 Hours of Hengrui Pharmaceutical
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The Dramatic 24 Hours of Hengrui Pharmaceutical
20 May 2024
programmed cell death protein 1 (PD-1) inhibitor carrelizumab and Rivoceranib in combination (hereinafter referred to as "Double Ai" combination) received a Complete Response Letter (CRL) from the FDA.
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Incyte Announces Acquisition of Escient Pharmaceuticals, Expanding First-in-Class Drug Pipeline Focused on MRGPRX2/MRGPRX4
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5 min read
Incyte Announces Acquisition of Escient Pharmaceuticals, Expanding First-in-Class Drug Pipeline Focused on MRGPRX2/MRGPRX4
20 May 2024
On April 23, global biopharmaceutical company Incyte announced the finalization of an agreement to fully acquire clinical-stage drug development company Escient Pharmaceuticals.
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Novartis continues to increase its investments in the "cyclic peptide + radiopharmaceuticals" therapeutic field
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5 min read
Novartis continues to increase its investments in the "cyclic peptide + radiopharmaceuticals" therapeutic field
11 May 2024
This acquisition will not only enrich Novartis's research and development pipeline in Radioligand Therapy (RLT) but will also enhance the company’s research foundation and clinical supply capabilities in oncology and RLT platform innovations.
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What ADC-related progress will CStone Pharmaceuticals reveal at the ASCO conference?
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2 min read
What ADC-related progress will CStone Pharmaceuticals reveal at the ASCO conference?
11 May 2024
The disclosed CS5001 is an ADC targeting ROR1, featuring a unique design.
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